Across TCGA patient cohorts, MAPT RNA expression is significantly associated with the protein abundance of many other proteins, with 25,011 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MAPT-associated proteins across cancer lineages are EPM2AIP1, EIF4G1, and GTPBP4. Each is linked with MAPT in more than 5 cancer types. Because this analysis shows association rather than direction, both MAPT-to-partner and partner-to-MAPT results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPT→partner) and Y-score (partner→MAPT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	EPM2AIP1 →	+0.511	+2.065	<.001	<.001	3	6
GBM	EIF4G1 →	-0.223	-1.029	.002	<.001	3	5
BRCA	GTPBP4 →	-0.490	-1.995	<.001	<.001	3	5
GBM	S100A12 →	-1.482	-1.055	<.001	<.001	3	5
GBM	AMPD3 →	-0.506	-0.744	<.001	<.001	3	5
GBM	ISG20 →	-0.678	-1.322	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 25,011 associations by consensus.

Exploration

MAPT survival (RNA) · tumor vs normal (RNA) · all MAPT data types