Across TCGA patient cohorts, MAPT protein abundance is significantly associated with the RNA expression of many other genes, with 12,784 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible MAPT-associated genes across cancer lineages are CDKL1, PPM1A, and ANKRD12. Each is linked with MAPT in more than 2 cancer types. Because this analysis shows association rather than direction, both MAPT-to-partner and partner-to-MAPT results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPT→partner) and Y-score (partner→MAPT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CDKL1 →	+0.606	+0.666	<.001	<.001	3	3
GBM	PPM1A →	+0.546	+0.475	<.001	<.001	3	3
GBM	ANKRD12 →	+0.494	+0.397	<.001	.001	3	3
BRCA	CAB39L →	+0.725	+0.545	.001	.009	3	3
BRCA	TRADD →	-0.489	-0.922	.005	<.001	3	3
BRCA	MAPK3 →	+0.624	+0.716	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,784 associations by consensus.

Exploration

MAPT survival (RNA) · tumor vs normal (RNA) · all MAPT data types