Across TCGA patient cohorts, MAPT mutation is significantly associated with the RNA expression of many other genes, with 3,282 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAPT-associated genes across cancer lineages are ATP6V1G1P4, RPL23AP94, and PHF5A. Each is linked with MAPT in more than 2 cancer types. Because this analysis shows association rather than direction, both MAPT-to-partner and partner-to-MAPT results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPT→partner) and Y-score (partner→MAPT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATP6V1G1P4 →	+0.172	+1.485	.007	.005	3	3
LUAD	RPL23AP94 →	+0.113	+4.061	<.001	.001	3	3
UCEC	PHF5A →	+0.449	+2.673	<.001	<.001	3	3
UCEC	EXOSC9 →	+0.453	+1.673	<.001	.003	3	3
UCEC	PDCD2L →	+0.347	+3.828	.005	<.001	3	3
UCEC	PSMC3IP →	+0.619	+3.108	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,282 associations by consensus.

Exploration

MAPT survival (RNA) · tumor vs normal (RNA) · all MAPT data types