Across TCGA patient cohorts, MAPT mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAPT-associated genes across cancer lineages are 4E-BP1, PKC-b-II_pS660, and C-Raf. Each is linked with MAPT in more than 2 cancer types. Because this analysis shows association rather than direction, both MAPT-to-partner and partner-to-MAPT results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPT→partner) and Y-score (partner→MAPT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	4E-BP1 →	+0.217	+1.882	.018	.031	3	3
COAD	PKC-b-II_pS660 →	-0.318	-3.169	.032	.018	3	2
COAD	C-Raf →	+0.164	+1.882	.007	.031	3	2
UCEC	JNK2 →	+0.220	+2.594	.001	.006	3	2
UCEC	STAT3_pY705 →	-0.315	-1.797	<.001	.025	3	2
UCEC	TIGAR →	+0.114	+2.901	.034	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Exploration

MAPT survival (RNA) · tumor vs normal (RNA) · all MAPT data types