Across TCGA cell cohorts, MAPT RNA expression is significantly associated with the go_rna of many other GO terms, with 5,336 significant associations in total. BONE shows the largest number of these associations.

The most reproducible MAPT-associated GO terms across cancer lineages are Potassium ion import across plasma membrane, Cellular response to brain-derived neurotrophic factor stimulus, and Intracellular distribution of mitochondria. Each is linked with MAPT in more than 12 cancer types. Because this analysis shows association rather than direction, both MAPT-to-partner and partner-to-MAPT results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPT→partner) and Y-score (partner→MAPT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Potassium ion import across plasma membrane →	-0.217	-0.761	<.001	.001	3	13
OVARY	Cellular response to brain-derived neurotrophic factor stimulus →	-0.153	-1.462	<.001	<.001	3	12
BLOOD_Myeloma	Intracellular distribution of mitochondria →	-0.171	-1.444	<.001	<.001	3	12
BONE	Positive regulation of sodium ion transmembrane transport →	-0.252	-3.917	<.001	<.001	3	11
BONE	Regulation of potassium ion transport →	-0.149	-4.205	<.001	<.001	3	11
LUNG_NSCLC_LUAD	Negative regulation of protein localization to mitochondrion →	-0.176	-1.278	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,336 associations by consensus.

Exploration

MAPT survival (RNA) · tumor vs normal (RNA) · all MAPT data types