Across TCGA cell cohorts, MAPT mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAPT-associated genes across cancer lineages are CCDC182, C12orf40, and MIOX. Each is linked with MAPT in more than 1 cancer types. Because this analysis shows association rather than direction, both MAPT-to-partner and partner-to-MAPT results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPT→partner) and Y-score (partner→MAPT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CCDC182 →	+0.026	+5.169	<.001	.004	3	1
SOFT_TISSUE	C12orf40 →	+0.383	+4.930	<.001	.008	3	1
LARGE_INTESTINE	MIOX →	+0.316	+3.241	<.001	.007	3	1
LARGE_INTESTINE	MAGEB4 →	+0.011	+3.415	<.001	.001	3	1
LARGE_INTESTINE	CCDC54 →	+0.096	+2.669	.003	.007	3	1
LARGE_INTESTINE	C8A →	+0.018	+2.777	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Exploration

MAPT survival (RNA) · tumor vs normal (RNA) · all MAPT data types