MAPRE3

Across TCGA patient cohorts, MAPRE3 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAPRE3-associated genes across cancer lineages are Rad50, 14-3-3_beta, and JNK2. Each is linked with MAPRE3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAPRE3-to-partner and partner-to-MAPRE3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by MAPRE3-low versus MAPRE3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPRE3→partner) and Y-score (partner→MAPRE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.300	-3.308	.003	.009	3	2
UCEC	14-3-3_beta →	-0.106	-2.209	.013	.011	3	1
UCEC	JNK2 →	+0.181	+2.834	.031	.034	3	1
UCEC	p27_pT198 →	+0.090	+2.906	.047	.001	3	1
UCEC	p62 Lck ligand →	+0.309	+3.179	.025	.010	3	1
UCEC	PDK1_pS241 →	+0.192	+2.459	.008	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Rad50 by MAPRE3 expression — UCEC

Explore this box plot interactively →