MAPRE2

Across TCGA patient cohorts, MAPRE2 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAPRE2-associated genes across cancer lineages are IRS1, MEK1, and Rad50. Each is linked with MAPRE2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAPRE2-to-partner and partner-to-MAPRE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IRS1 grouped by MAPRE2-low versus MAPRE2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPRE2→partner) and Y-score (partner→MAPRE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IRS1 →	-0.203	-3.321	.025	.009	3	2
UCEC	MEK1 →	+0.401	+3.584	.012	.002	3	2
UCEC	Rad50 →	-0.236	-2.115	.026	.019	3	2
UCEC	ATM →	-0.679	-3.584	<.001	.002	3	2
UCEC	eIF4E →	+0.197	+2.115	.032	.019	3	1
UCEC	GATA6 →	-0.164	-2.108	.015	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

IRS1 by MAPRE2 expression — UCEC

Explore this box plot interactively →