MAPRE1

Across TCGA patient cohorts, MAPRE1 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAPRE1-associated genes across cancer lineages are N-Cadherin, EGFR_pY1068, and INPP4B. Each is linked with MAPRE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAPRE1-to-partner and partner-to-MAPRE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, N-Cadherin grouped by MAPRE1-low versus MAPRE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPRE1→partner) and Y-score (partner→MAPRE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	N-Cadherin →	+0.323	+3.009	.001	.019	3	2
UCEC	EGFR_pY1068 →	-0.246	-3.000	.042	.036	3	1
UCEC	INPP4B →	-0.358	-3.321	.022	.009	3	1
UCEC	JNK2 →	+0.274	+2.331	.004	.019	3	1
UCEC	Ku80 →	+0.271	+2.183	.017	.033	3	1
UCEC	NDRG1_pT346 →	-0.476	-3.000	.044	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

N-Cadherin by MAPRE1 expression — UCEC

Explore this box plot interactively →