MAPKBP1

Across TCGA patient cohorts, MAPKBP1 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAPKBP1-associated genes across cancer lineages are p70-S6K, eIF4E, and GAPDH. Each is linked with MAPKBP1 in more than 3 cancer types. Because this analysis shows association rather than direction, both MAPKBP1-to-partner and partner-to-MAPKBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p70-S6K grouped by MAPKBP1-low versus MAPKBP1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPKBP1→partner) and Y-score (partner→MAPKBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	p70-S6K →	+0.290	+3.000	.027	.036	3	4
UCEC	eIF4E →	+0.191	+2.736	.004	<.001	3	3
UCEC	GAPDH →	+0.388	+1.678	.021	.019	3	3
UCEC	4E-BP1 →	+0.415	+3.351	<.001	<.001	2	4
UCEC	C-Raf →	+0.178	+1.584	<.001	.008	3	3
COAD	eEF2 →	+0.441	+2.178	.001	.035	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

p70-S6K by MAPKBP1 expression — STAD

Explore this box plot interactively →