MAPKBP1

Across TCGA cell cohorts, MAPKBP1 mutation is significantly associated with the RNA expression of many other genes, with 50 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MAPKBP1-associated genes across cancer lineages are AQP12A, BPIFB2, and OR4C6. Each is linked with MAPKBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAPKBP1-to-partner and partner-to-MAPKBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AQP12A grouped by MAPKBP1-low versus MAPKBP1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPKBP1→partner) and Y-score (partner→MAPKBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	AQP12A →	+0.092	+3.362	<.001	.001	3	2
BLOOD_Leukemia	BPIFB2 →	+0.019	+3.181	.009	.001	3	2
SOFT_TISSUE	OR4C6 →	+0.039	+4.369	<.001	.008	3	1
SOFT_TISSUE	SPRR2F →	+0.091	+4.635	.004	.003	3	1
SKIN	ALAS2 →	+0.073	+3.591	<.001	.002	3	1
SKIN	ALAS1 →	+0.598	+3.087	.009	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

AQP12A by MAPKBP1 expression — BLOOD_Leukemia

Explore this box plot interactively →