MAPKAPK3

Across TCGA pan-cancer cohorts, MAPKAPK3 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of MAPKAPK3’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where MAPKAPK3 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types MAPKAPK3 is over-expressed in tumor, although a few such as HNSC and LSCC show the opposite, repressed pattern.

COAD, HNSC, and LSCC are the cancer types where MAPKAPK3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MAPKAPK3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	+0.287	<.001	8	view →
HNSC	All	IV	−0.277	<.001	8	view →
LSCC	All	II,III,IV	−0.213	<.001	5	view →
CCRCC	All	All	+0.083	.004	5	view →
PDAC	All	All	+0.171	.003	4	view →
LUAD	All	All	+0.102	.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

MAPKAPK3–COAD

Open the COAD breakdown →