MAPKAPK3

Across TCGA cell cohorts, MAPKAPK3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,171 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MAPKAPK3-associated GO terms across cancer lineages are Actin filament depolymerization, Protein depolymerization, and Nucleosome disassembly. Each is linked with MAPKAPK3 in more than 9 cancer types. Because this analysis shows association rather than direction, both MAPKAPK3-to-partner and partner-to-MAPKAPK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Actin filament depolymerization grouped by MAPKAPK3-low versus MAPKAPK3-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPKAPK3→partner) and Y-score (partner→MAPKAPK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Actin filament depolymerization →	+0.182	+1.562	.002	.008	3	10
SOFT_TISSUE	Protein depolymerization →	+0.107	+1.557	<.001	<.001	3	10
URINARY_TRACT	Nucleosome disassembly →	+0.127	+1.237	<.001	<.001	3	10
LARGE_INTESTINE	Regulation of Wnt protein secretion →	+0.068	+0.522	.001	<.001	3	9
BLOOD_Leukemia	Regulation of cell-matrix adhesion →	+0.037	+0.844	<.001	<.001	3	9
KIDNEY	Establishment of protein localization to postsynaptic membrane →	+0.145	+1.375	.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,171 associations by consensus.

Actin filament depolymerization by MAPKAPK3 expression — URINARY_TRACT

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