MAPKAPK3

Across TCGA cell cohorts, MAPKAPK3 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible MAPKAPK3-associated genes across cancer lineages are PPP3R2, ZNRF4, and TSPY8. Each is linked with MAPKAPK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAPKAPK3-to-partner and partner-to-MAPKAPK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP3R2 grouped by MAPKAPK3-low versus MAPKAPK3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPKAPK3→partner) and Y-score (partner→MAPKAPK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PPP3R2 →	+0.048	+3.884	<.001	.005	3	1
LUNG_NSCLC_LUAD	ZNRF4 →	+0.012	+4.887	.001	.009	3	1
LUNG_NSCLC_LUAD	TSPY8 →	+0.261	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	TEX50 →	+0.071	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

PPP3R2 by MAPKAPK3 expression — LARGE_INTESTINE

Explore this box plot interactively →