MAPKAPK2

Across TCGA cell cohorts, MAPKAPK2 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MAPKAPK2-associated genes across cancer lineages are OR1D4 and DPPA5. Each is linked with MAPKAPK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAPKAPK2-to-partner and partner-to-MAPKAPK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1D4 grouped by MAPKAPK2-low versus MAPKAPK2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPKAPK2→partner) and Y-score (partner→MAPKAPK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR1D4 →	+0.069	+5.539	<.001	.003	3	1
CNS	DPPA5 →	+0.050	+4.981	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

OR1D4 by MAPKAPK2 expression — BLOOD_Leukemia

Explore this box plot interactively →