MAPKAP1

Across TCGA patient cohorts, MAPKAP1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAPKAP1-associated genes across cancer lineages are TFRC, Tuberin_pT1462, and c-Met_pY1235. Each is linked with MAPKAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAPKAP1-to-partner and partner-to-MAPKAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by MAPKAP1-low versus MAPKAP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPKAP1→partner) and Y-score (partner→MAPKAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.629	+3.584	<.001	.002	3	2
UCEC	Tuberin_pT1462 →	+0.189	+1.495	.020	.034	3	2
UCEC	c-Met_pY1235 →	+0.059	+1.495	.023	.034	3	2
UCEC	4E-BP1 →	+0.288	+3.321	.002	.009	3	2
UCEC	Cyclin-B1 →	+0.601	+3.459	.002	.005	3	2
UCEC	eIF4E →	+0.173	+2.598	.020	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

TFRC by MAPKAP1 expression — UCEC

Explore this box plot interactively →