MAPKAP1

Across TCGA cell cohorts, MAPKAP1 mutation is significantly associated with the RNA expression of many other genes, with 166 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAPKAP1-associated genes across cancer lineages are GCAT, SH3GL2, and MINPP1. Each is linked with MAPKAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAPKAP1-to-partner and partner-to-MAPKAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GCAT grouped by MAPKAP1-low versus MAPKAP1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPKAP1→partner) and Y-score (partner→MAPKAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GCAT →	+1.467	+3.212	<.001	.006	3	1
LARGE_INTESTINE	SH3GL2 →	+1.493	+3.474	<.001	.003	3	1
LARGE_INTESTINE	MINPP1 →	+0.769	+3.299	<.001	.004	3	1
LARGE_INTESTINE	NCAPG →	+0.692	+3.212	.003	.006	3	1
LARGE_INTESTINE	ULBP1 →	+0.920	+3.212	.006	.006	3	1
LARGE_INTESTINE	CCNG1 →	+0.748	+3.212	.003	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 166 associations by consensus.

GCAT by MAPKAP1 expression — LARGE_INTESTINE

Explore this box plot interactively →