MAPK8IP1

Across TCGA patient cohorts, MAPK8IP1 mutation is significantly associated with the RNA expression of many other genes, with 2,405 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAPK8IP1-associated genes across cancer lineages are GMNN, CENPU, and DONSON. Each is linked with MAPK8IP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAPK8IP1-to-partner and partner-to-MAPK8IP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GMNN grouped by MAPK8IP1-low versus MAPK8IP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPK8IP1→partner) and Y-score (partner→MAPK8IP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GMNN →	+0.599	+2.136	<.001	<.001	3	3
UCEC	CENPU →	+0.523	+2.147	.004	<.001	3	3
COAD	DONSON →	+0.530	+2.625	<.001	.005	3	3
UCEC	H2AZ1 →	+0.591	+1.868	<.001	<.001	3	3
UCEC	ATP5PD →	+0.305	+2.807	.006	<.001	3	3
UCEC	LSM3 →	+0.464	+2.115	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,405 associations by consensus.

GMNN by MAPK8IP1 expression — UCEC

Explore this box plot interactively →