MAPK8IP1

Across TCGA cell cohorts, MAPK8IP1 mutation is significantly associated with the RNA expression of many other genes, with 840 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAPK8IP1-associated genes across cancer lineages are GCAT, HSCB, and CBY1. Each is linked with MAPK8IP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAPK8IP1-to-partner and partner-to-MAPK8IP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GCAT grouped by MAPK8IP1-low versus MAPK8IP1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPK8IP1→partner) and Y-score (partner→MAPK8IP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GCAT →	+1.279	+3.584	<.001	<.001	3	1
LARGE_INTESTINE	HSCB →	+0.621	+3.584	<.001	<.001	3	1
LARGE_INTESTINE	CBY1 →	+0.741	+2.619	<.001	.001	3	1
LARGE_INTESTINE	MIOX →	+0.218	+3.257	.004	.002	3	1
LARGE_INTESTINE	HMGXB4 →	+0.460	+2.158	.007	.004	3	1
LARGE_INTESTINE	CNIH1 →	+0.536	+3.321	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 840 associations by consensus.

GCAT by MAPK8IP1 expression — LARGE_INTESTINE

Explore this box plot interactively →