MAPK8

Across TCGA patient cohorts, MAPK8 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAPK8-associated genes across cancer lineages are PCNA, Caspase-7-cleavedD198, and MSH2. Each is linked with MAPK8 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAPK8-to-partner and partner-to-MAPK8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by MAPK8-low versus MAPK8-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPK8→partner) and Y-score (partner→MAPK8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PCNA →	+0.274	+2.815	.044	.036	3	2
UCEC	Caspase-7-cleavedD198 →	+0.557	+2.222	.027	.011	3	2
UCEC	MSH2 →	-0.241	-2.973	.013	.035	3	1
UCEC	PDCD4 →	-0.502	-2.222	.011	.011	3	1
UCEC	Annexin-1 →	+0.657	+3.321	.003	.009	3	1
UCEC	SCD →	+0.098	+1.713	.036	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

PCNA by MAPK8 expression — COAD

Explore this box plot interactively →