MAPK8

Across TCGA cell cohorts, MAPK8 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,323 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MAPK8-associated GO terms across cancer lineages are Negative regulation of binding, Negative regulation of protein binding, and Peptidyl-serine phosphorylation. Each is linked with MAPK8 in more than 14 cancer types. Because this analysis shows association rather than direction, both MAPK8-to-partner and partner-to-MAPK8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of binding grouped by MAPK8-low versus MAPK8-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPK8→partner) and Y-score (partner→MAPK8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of binding →	+0.118	+1.037	<.001	<.001	3	15
LUNG_SCLC	Negative regulation of protein binding →	+0.123	+0.969	.001	<.001	3	14
LUNG_SCLC	Peptidyl-serine phosphorylation →	+0.059	+0.576	.002	.001	3	13
LIVER	Nuclear envelope organization →	+0.070	+0.733	.002	.005	2	14
BLOOD_Myeloma	Positive regulation of organelle assembly →	+0.064	+0.973	<.001	.002	3	12
LUNG_SCLC	Peptidyl-serine modification →	+0.061	+0.599	.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,323 associations by consensus.

Negative regulation of binding by MAPK8 expression — BONE

Explore this box plot interactively →