MAPK7

Across TCGA patient cohorts, MAPK7 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAPK7-associated genes across cancer lineages are Caspase-7-cleavedD198, MEK1, and PCNA. Each is linked with MAPK7 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAPK7-to-partner and partner-to-MAPK7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by MAPK7-low versus MAPK7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPK7→partner) and Y-score (partner→MAPK7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.889	+2.242	<.001	.005	3	3
UCEC	MEK1 →	+0.432	+2.392	<.001	<.001	3	2
UCEC	PCNA →	+0.210	+1.662	.005	.011	3	2
UCEC	Chk2_pT68 →	-0.194	-3.880	.003	<.001	3	2
UCEC	4E-BP1 →	+0.213	+1.362	.026	.037	3	2
UCEC	eIF4E →	+0.223	+2.874	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Caspase-7-cleavedD198 by MAPK7 expression — UCEC

Explore this box plot interactively →