MAPK7

Across TCGA cell cohorts, MAPK7 mutation is significantly associated with the RNA expression of many other genes, with 166 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAPK7-associated genes across cancer lineages are IL31, ZNF232, and MYH6. Each is linked with MAPK7 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAPK7-to-partner and partner-to-MAPK7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL31 grouped by MAPK7-low versus MAPK7-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPK7→partner) and Y-score (partner→MAPK7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	IL31 →	+0.032	+4.977	<.001	.007	3	2
LARGE_INTESTINE	ZNF232 →	+0.873	+3.364	<.001	.002	3	2
PANCREAS	MYH6 →	+0.006	+5.000	<.001	.006	3	1
BLOOD_Leukemia	VSX2 →	+0.024	+2.995	<.001	.003	3	1
BLOOD_Leukemia	ACP7 →	+0.019	+3.815	<.001	<.001	3	1
CNS	GPR101 →	+0.474	+4.169	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 166 associations by consensus.

IL31 by MAPK7 expression — SKIN

Explore this box plot interactively →