MAPK4

Across TCGA patient cohorts, MAPK4 mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAPK4-associated genes across cancer lineages are Chk1, Caspase-7-cleavedD198, and Bid. Each is linked with MAPK4 in more than 2 cancer types. Because this analysis shows association rather than direction, both MAPK4-to-partner and partner-to-MAPK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chk1 grouped by MAPK4-low versus MAPK4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPK4→partner) and Y-score (partner→MAPK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Chk1 →	+0.169	+2.239	.005	.004	3	3
UCEC	Caspase-7-cleavedD198 →	+0.465	+1.382	.011	.021	3	3
COAD	Bid →	+0.129	+3.195	.021	.010	3	2
SKCM	MEK1_p_S217_S221 →	+0.200	+1.427	.007	.026	3	2
UCEC	MSH2 →	-0.223	-2.196	.001	.009	3	2
UCEC	PARP_cleaved →	-0.221	-2.736	.021	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

Chk1 by MAPK4 expression — SKCM

Explore this box plot interactively →