MAPK4

Across TCGA cell cohorts, MAPK4 mutation is significantly associated with the RNA expression of many other genes, with 41 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAPK4-associated genes across cancer lineages are SLC22A24, SLC35G4, and GHRH. Each is linked with MAPK4 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAPK4-to-partner and partner-to-MAPK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC22A24 grouped by MAPK4-low versus MAPK4-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPK4→partner) and Y-score (partner→MAPK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SLC22A24 →	+0.006	+4.906	<.001	.006	3	2
OESOPHAGUS	SLC35G4 →	+0.020	+4.906	<.001	.006	3	1
SKIN	GHRH →	+0.697	+4.273	<.001	.006	3	1
SKIN	HMHB1 →	+0.057	+5.022	<.001	.002	3	1
LARGE_INTESTINE	MEAF6 →	+0.641	+3.087	<.001	.006	3	1
LARGE_INTESTINE	SLC25A33 →	+0.741	+3.082	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

SLC22A24 by MAPK4 expression — OESOPHAGUS

Explore this box plot interactively →