MAPK4

Across TCGA cell cohorts, MAPK4 mutation is significantly associated with the mutation status of many other genes, with 4,824 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAPK4-associated genes across cancer lineages are NLRP10, ZSWIM8, and KDM2B. Each is linked with MAPK4 in more than 3 cancer types. Because this analysis shows association rather than direction, both MAPK4-to-partner and partner-to-MAPK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NLRP10 grouped by MAPK4-low versus MAPK4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPK4→partner) and Y-score (partner→MAPK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NLRP10 →	+3.548	+3.845	.003	.003	1	4
BLOOD_Leukemia	ZSWIM8 →	+2.870	+3.347	.009	.009	1	4
BLOOD_Leukemia	KDM2B →	+2.825	+3.847	.001	.001	1	4
BLOOD_Lymphoma	HINFP →	+4.832	+4.832	<.001	<.001	1	4
BLOOD_Lymphoma	HCFC1 →	+3.025	+3.754	.006	.006	1	4
SKIN	PLK2 →	+5.053	+4.239	.007	.007	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,824 associations by consensus.

NLRP10 by MAPK4 expression — BLOOD_Leukemia

Explore this box plot interactively →