MAPK3

Across TCGA patient cohorts, MAPK3 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAPK3-associated genes across cancer lineages are PCNA, MEK1, and PRDX1. Each is linked with MAPK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAPK3-to-partner and partner-to-MAPK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by MAPK3-low versus MAPK3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPK3→partner) and Y-score (partner→MAPK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.283	+3.169	.009	.019	3	2
UCEC	MEK1 →	+0.453	+3.459	.013	.005	3	1
UCEC	PRDX1 →	+0.269	+3.000	.009	.036	2	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

PCNA by MAPK3 expression — UCEC

Explore this box plot interactively →