MAPK3

Across TCGA cell cohorts, MAPK3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,605 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MAPK3-associated GO terms across cancer lineages are Interleukin-34-mediated signaling pathway, Regulation of Golgi inheritance, and Positive regulation of macrophage proliferation. Each is linked with MAPK3 in more than 16 cancer types. Because this analysis shows association rather than direction, both MAPK3-to-partner and partner-to-MAPK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Interleukin-34-mediated signaling pathway grouped by MAPK3-low versus MAPK3-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPK3→partner) and Y-score (partner→MAPK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Interleukin-34-mediated signaling pathway →	+0.233	+1.442	<.001	<.001	3	17
OVARY	Regulation of Golgi inheritance →	+0.181	+1.170	<.001	<.001	3	17
KIDNEY	Positive regulation of macrophage proliferation →	+0.206	+0.941	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Regulation of macrophage proliferation →	+0.300	+1.543	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Caveolin-mediated endocytosis →	+0.247	+1.442	<.001	<.001	3	13
LUNG_NSCLC_LUAD	ERBB3 signaling pathway →	+0.238	+1.049	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,605 associations by consensus.

Interleukin-34-mediated signaling pathway by MAPK3 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →