MAPK3

Across TCGA cell cohorts, MAPK3 mutation is significantly associated with the drug of many other genes, with 28 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAPK3-associated genes across cancer lineages are Niraparib, Luminespib, and PCI-34051. Each is linked with MAPK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAPK3-to-partner and partner-to-MAPK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Niraparib grouped by MAPK3-low versus MAPK3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPK3→partner) and Y-score (partner→MAPK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Niraparib →	+0.413	+2.646	.019	.047	3	1
LARGE_INTESTINE	Luminespib →	+0.865	+2.646	.003	.047	3	1
LARGE_INTESTINE	PCI-34051 →	+0.401	+2.646	.037	.047	3	1
LARGE_INTESTINE	PAK_5339 →	+0.420	+2.678	.004	.037	3	1
LARGE_INTESTINE	KIN001-236 →	+0.294	+2.652	.041	.045	3	1
LARGE_INTESTINE	SNX-2112 →	+0.775	+2.652	.027	.045	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Niraparib by MAPK3 expression — LARGE_INTESTINE

Explore this box plot interactively →