MAPK14

Across TCGA pan-cancer cohorts, MAPK14 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MAPK14 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher MAPK14 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MAPK14 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

COAD, HNSC, and LSCC are the cancer types where MAPK14 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.884	1.000	.017	30	view →
HNSC	OS	Quartile	IV	1.000	0.729	.007	14	view →
LSCC	OS	Tertile	III,IV	0.928	0.512	.009	13	view →
GBM	DFS	Median	All	0.668	0.828	.004	11	view →
CCRCC	DFS	Median	II,III,IV	1.000	0.514	.022	3	view →
PDAC	DFS	Quartile	II,III,IV	0.578	0.809	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MAPK14–COAD (DFS)

Open the COAD breakdown →