MAPK14

Across TCGA patient cohorts, MAPK14 protein abundance is significantly associated with the protein abundance of many other proteins, with 26,066 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MAPK14-associated proteins across cancer lineages are MAPKAPK2, MAPKAPK3, and DEF6. Each is linked with MAPK14 in more than 8 cancer types. Because this analysis shows association rather than direction, both MAPK14-to-partner and partner-to-MAPK14 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MAPK14 versus MAPKAPK2 in GBM, with a Pearson correlation of 0.81.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPK14→partner) and Y-score (partner→MAPK14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MAPKAPK2 →	+0.386	+0.378	<.001	<.001	3	9
GBM	MAPKAPK3 →	+0.378	+0.331	<.001	<.001	3	9
GBM	DEF6 →	+0.446	+0.182	<.001	<.001	3	8
GBM	ALOX5 →	+0.687	+0.280	<.001	<.001	3	8
GBM	PYCARD →	+0.528	+0.247	<.001	<.001	3	8
GBM	DOCK8 →	+0.471	+0.266	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 26,066 associations by consensus.

MAPK14 vs MAPKAPK2 — GBM

Explore this scatter interactively →