MAPK14

Across TCGA patient cohorts, MAPK14 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAPK14-associated genes across cancer lineages are Stathmin, ATM, and 14-3-3_beta. Each is linked with MAPK14 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAPK14-to-partner and partner-to-MAPK14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Stathmin grouped by MAPK14-low versus MAPK14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPK14→partner) and Y-score (partner→MAPK14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Stathmin →	+0.151	+2.736	.002	<.001	3	2
UCEC	ATM →	-0.684	-3.794	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.073	-2.295	.048	.033	3	1
UCEC	EGFR_pY1068 →	-0.342	-2.736	<.001	<.001	3	1
UCEC	FoxM1 →	+0.317	+2.736	<.001	<.001	3	1
UCEC	GATA6 →	-0.169	-3.444	.004	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

Stathmin by MAPK14 expression — UCEC

Explore this box plot interactively →