Across TCGA patient cohorts, MAPK12 mutation is significantly associated with the RNA expression of many other genes, with 163 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAPK12-associated genes across cancer lineages are FAM242D, RNU6-1140P, and IGHD4-17. Each is linked with MAPK12 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAPK12-to-partner and partner-to-MAPK12 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPK12→partner) and Y-score (partner→MAPK12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	FAM242D →	+0.061	+5.459	<.001	.005	3	2
UCEC	RNU6-1140P →	+0.313	+2.048	.001	.008	3	2
UCEC	IGHD4-17 →	+0.540	+2.492	.001	.008	3	2
SKCM	SNRPCP15 →	+0.163	+4.199	<.001	.009	3	2
HNSC	ACTR3BP6 →	+0.029	+7.954	<.001	.008	3	1
CESC	SCP2D1-AS1 →	+0.098	+4.455	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 163 associations by consensus.

Exploration

MAPK12 survival (RNA) · tumor vs normal (RNA) · all MAPK12 data types