Across TCGA patient cohorts, MAPK12 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAPK12-associated genes across cancer lineages are NDRG1_pT346, PKC-a, and p62 Lck ligand. Each is linked with MAPK12 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAPK12-to-partner and partner-to-MAPK12 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPK12→partner) and Y-score (partner→MAPK12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NDRG1_pT346 →	-0.431	-2.999	.044	.035	3	1
UCEC	PKC-a →	+0.375	+3.000	.034	.036	3	1
UCEC	p62 Lck ligand →	+0.340	+2.115	.016	.019	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Exploration

MAPK12 survival (RNA) · tumor vs normal (RNA) · all MAPK12 data types