Across TCGA cell cohorts, MAPK12 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MAPK12-associated genes across cancer lineages are OLIG3, OR4D9, and KRTAP11-1. Each is linked with MAPK12 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAPK12-to-partner and partner-to-MAPK12 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPK12→partner) and Y-score (partner→MAPK12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OLIG3 →	+0.025	+4.510	.002	.001	3	1
BLOOD_Leukemia	OR4D9 →	+0.003	+4.384	<.001	.006	3	1
BLOOD_Leukemia	KRTAP11-1 →	+0.025	+4.384	<.001	.006	3	1
BLOOD_Leukemia	PNLIPRP3 →	+0.008	+3.551	.007	.009	3	1
BLOOD_Leukemia	CD300LD →	+0.424	+3.551	<.001	.009	3	1
BLOOD_Leukemia	HTN3 →	+0.313	+3.551	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

MAPK12 survival (RNA) · tumor vs normal (RNA) · all MAPK12 data types