Across TCGA patient cohorts, MAPK11 mutation is significantly associated with the RNA expression of many other genes, with 165 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAPK11-associated genes across cancer lineages are RN7SL447P, HMGB1P50, and OR7E157P. Each is linked with MAPK11 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAPK11-to-partner and partner-to-MAPK11 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPK11→partner) and Y-score (partner→MAPK11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL447P →	+0.305	+3.418	<.001	<.001	3	2
UCEC	HMGB1P50 →	+0.204	+2.413	<.001	.005	3	1
COAD	OR7E157P →	+0.064	+5.145	<.001	.007	3	1
COAD	PUDPP2 →	+0.054	+5.212	.001	.007	3	1
COAD	RNU4ATAC4P →	+0.396	+5.283	.008	.006	3	1
COAD	OR56A7P →	+0.100	+6.547	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 165 associations by consensus.

Exploration

MAPK11 survival (RNA) · tumor vs normal (RNA) · all MAPK11 data types