MAPK11

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, MAPK11 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAPK11-associated genes across cancer lineages are Annexin-1, c-Kit, and MSH2. Each is linked with MAPK11 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAPK11-to-partner and partner-to-MAPK11 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPK11→partner) and Y-score (partner→MAPK11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECAnnexin-1 →+1.137+2.827<.001.03532
UCECc-Kit →-0.289-3.000.032.03721
UCECMSH2 →-0.367-3.000.005.03711
UCECC-Raf_pS338 →-0.119-3.000.011.03711
Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Exploration