Across TCGA cell cohorts, MAPK11 mutation is significantly associated with the RNA expression of many other genes, with 416 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAPK11-associated genes across cancer lineages are SLC2A7, APOL5, and SMIM23. Each is linked with MAPK11 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAPK11-to-partner and partner-to-MAPK11 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPK11→partner) and Y-score (partner→MAPK11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	SLC2A7 →	+0.013	+4.643	<.001	.008	3	1
BLOOD_Leukemia	APOL5 →	+0.015	+5.060	<.001	.001	3	1
BLOOD_Leukemia	SMIM23 →	+0.022	+5.569	<.001	.001	3	1
BLOOD_Leukemia	OR10T2 →	+0.707	+4.276	<.001	.007	3	1
BLOOD_Leukemia	OR10R2 →	+2.034	+4.551	<.001	.004	3	1
LARGE_INTESTINE	EIF3L →	+0.599	+3.067	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 416 associations by consensus.

Exploration

MAPK11 survival (RNA) · tumor vs normal (RNA) · all MAPK11 data types