MAPK10

Across TCGA patient cohorts, MAPK10 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAPK10-associated genes across cancer lineages are EGFR_pY1068, PKC-a_pS657, and c-Kit. Each is linked with MAPK10 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAPK10-to-partner and partner-to-MAPK10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by MAPK10-low versus MAPK10-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPK10→partner) and Y-score (partner→MAPK10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	EGFR_pY1068 →	+0.419	+3.012	.042	.018	3	2
BLCA	PKC-a_pS657 →	-0.419	-3.459	.004	.005	3	2
BLCA	c-Kit →	-0.330	-3.169	.031	.018	3	2
UCEC	ERK2 →	+0.142	+1.247	.030	.045	3	2
UCEC	Notch1 →	+0.202	+2.335	<.001	.002	3	2
UCEC	Shc_pY317 →	-0.192	-1.807	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

EGFR_pY1068 by MAPK10 expression — BLCA

Explore this box plot interactively →