MAPK10

Across TCGA cell cohorts, MAPK10 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,350 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible MAPK10-associated GO terms across cancer lineages are Regulation of myoblast fusion, Vesicle coating, and Proteasomal ubiquitin-independent protein catabolic process. Each is linked with MAPK10 in more than 9 cancer types. Because this analysis shows association rather than direction, both MAPK10-to-partner and partner-to-MAPK10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of myoblast fusion grouped by MAPK10-low versus MAPK10-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPK10→partner) and Y-score (partner→MAPK10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Regulation of myoblast fusion →	+0.060	+0.648	.001	.001	3	10
LUNG_SCLC	Vesicle coating →	+0.077	+1.350	<.001	.001	3	10
URINARY_TRACT	Proteasomal ubiquitin-independent protein catabolic process →	+0.087	+1.570	.001	.002	2	10
STOMACH	Regulation of syncytium formation by plasma membrane fusion →	+0.106	+1.162	.001	.009	3	9
UPPER_AERODIGESTIVE_TRACT	Transposable element silencing by mRNA destabilization →	+0.153	+1.189	<.001	.003	3	8
LIVER	Negative regulation of protein catabolic process →	+0.074	+1.076	.004	.007	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,350 associations by consensus.

Regulation of myoblast fusion by MAPK10 expression — LARGE_INTESTINE

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