MAPK10

Across TCGA cell cohorts, MAPK10 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. CNS shows the largest number of these associations.

The most reproducible MAPK10-associated genes across cancer lineages are APCS, SPZ1, and RNASE3. Each is linked with MAPK10 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAPK10-to-partner and partner-to-MAPK10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, APCS grouped by MAPK10-low versus MAPK10-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPK10→partner) and Y-score (partner→MAPK10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	APCS →	+0.174	+4.643	<.001	.003	3	1
CNS	SPZ1 →	+0.030	+4.169	<.001	.008	3	1
CNS	RNASE3 →	+0.055	+4.169	.007	.008	3	1
CNS	OR10G7 →	+0.010	+5.357	<.001	.001	3	1
CNS	SCGB1C1 →	+0.299	+5.566	<.001	<.001	3	1
CNS	TARM1 →	+0.024	+4.321	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

APCS by MAPK10 expression — CNS

Explore this box plot interactively →