MAPK1

Across TCGA patient cohorts, MAPK1 protein abundance is significantly associated with the RNA expression of many other genes, with 16,125 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MAPK1-associated genes across cancer lineages are SPECC1L, PEA15, and UBE2L3. Each is linked with MAPK1 in more than 5 cancer types. Because this analysis shows association rather than direction, both MAPK1-to-partner and partner-to-MAPK1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MAPK1 versus SPECC1L in OV, with a Pearson correlation of 0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPK1→partner) and Y-score (partner→MAPK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SPECC1L →	+0.559	+0.264	<.001	.002	3	6
UCEC	PEA15 →	+0.531	+0.274	.007	<.001	3	6
HNSC	UBE2L3 →	+0.601	+0.301	<.001	<.001	3	5
OV	C22orf39 →	+0.537	+0.244	<.001	<.001	3	5
OV	PPM1F →	+0.543	+0.228	.001	.003	3	4
OV	GRK3 →	+0.667	+0.309	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,125 associations by consensus.

MAPK1 vs SPECC1L — OV

Explore this scatter interactively →