MAPK1

Across TCGA patient cohorts, MAPK1 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAPK1-associated genes across cancer lineages are eIF4E, eIF4G, and A-Raf_pS299. Each is linked with MAPK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAPK1-to-partner and partner-to-MAPK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by MAPK1-low versus MAPK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAPK1→partner) and Y-score (partner→MAPK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.208	+2.584	.010	.001	3	1
UCEC	eIF4G →	+0.268	+1.678	.024	.023	3	1
UCEC	A-Raf_pS299 →	-0.127	-2.087	.005	.005	3	1
UCEC	INPP4B →	-0.355	-3.700	.004	.001	3	1
UCEC	JNK_pT183_Y185 →	-0.202	-2.571	.001	.001	3	1
UCEC	Notch1 →	+0.151	+1.678	.005	.023	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

eIF4E by MAPK1 expression — UCEC

Explore this box plot interactively →