MAP7D1

Across TCGA patient cohorts, MAP7D1 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP7D1-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and ERK2. Each is linked with MAP7D1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP7D1-to-partner and partner-to-MAP7D1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by MAP7D1-low versus MAP7D1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP7D1→partner) and Y-score (partner→MAP7D1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+1.333	+3.479	<.001	.002	3	2
UCEC	EGFR_pY1068 →	-0.230	-2.584	.049	.011	3	1
UCEC	ERK2 →	+0.217	+3.169	.015	.018	3	1
UCEC	Lck →	+0.226	+2.584	.015	.011	3	1
UCEC	MEK1 →	+0.493	+3.321	.003	.010	3	1
UCEC	mTOR_pS2448 →	-0.179	-2.584	.010	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Caspase-7-cleavedD198 by MAP7D1 expression — UCEC

Explore this box plot interactively →