MAP7

Across TCGA patient cohorts, MAP7 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP7-associated genes across cancer lineages are PCNA, S6_pS240_S244, and ARID1A. Each is linked with MAP7 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP7-to-partner and partner-to-MAP7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by MAP7-low versus MAP7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP7→partner) and Y-score (partner→MAP7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.274	+2.247	<.001	.001	3	2
UCEC	S6_pS240_S244 →	+0.357	+2.115	.016	.017	3	2
UCEC	ARID1A →	-0.191	-3.321	.005	.009	3	2
UCEC	STAT3_pY705 →	-0.411	-2.700	<.001	.005	3	2
UCEC	ATM →	-0.520	-2.102	.001	.016	3	2
UCEC	C-Raf →	+0.180	+1.847	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

PCNA by MAP7 expression — UCEC

Explore this box plot interactively →