MAP7

Across TCGA cell cohorts, MAP7 mutation is significantly associated with the RNA expression of many other genes, with 417 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MAP7-associated genes across cancer lineages are NDUFAF1, SIGLEC16, and CTDNEP1. Each is linked with MAP7 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP7-to-partner and partner-to-MAP7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFAF1 grouped by MAP7-low versus MAP7-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP7→partner) and Y-score (partner→MAP7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NDUFAF1 →	+0.567	+3.364	.001	.002	3	2
LARGE_INTESTINE	SIGLEC16 →	+0.097	+2.658	<.001	.008	3	2
LARGE_INTESTINE	CTDNEP1 →	+0.556	+3.364	.001	.002	3	2
STOMACH	CYP11B2 →	+0.006	+5.285	<.001	.003	3	1
STOMACH	BOD1L2 →	+0.006	+5.285	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	PRRG3 →	+0.249	+4.209	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 417 associations by consensus.

NDUFAF1 by MAP7 expression — LARGE_INTESTINE

Explore this box plot interactively →