MAP4K5

Across TCGA patient cohorts, MAP4K5 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MAP4K5-associated genes across cancer lineages are JNK_pT183_Y185, MEK1, and Shc_pY317. Each is linked with MAP4K5 in more than 1 cancer types. Because this analysis shows association rather than direction, both MAP4K5-to-partner and partner-to-MAP4K5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by MAP4K5-low versus MAP4K5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP4K5→partner) and Y-score (partner→MAP4K5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.163	-1.861	.003	.002	3	2
UCEC	MEK1 →	+0.369	+1.925	.002	.004	3	2
UCEC	Shc_pY317 →	-0.147	-2.459	.003	.018	3	2
UCEC	ATM →	-0.479	-2.571	.001	.010	3	2
UCEC	Caspase-7-cleavedD198 →	+0.587	+1.785	.003	.007	3	2
UCEC	C-Raf →	+0.139	+2.000	.003	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

JNK_pT183_Y185 by MAP4K5 expression — UCEC

Explore this box plot interactively →