MAP4K5

Across TCGA cell cohorts, MAP4K5 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,327 significant associations in total. BONE shows the largest number of these associations.

The most reproducible MAP4K5-associated GO terms across cancer lineages are Negative regulation of cilium assembly, Microtubule polymerization, and Vesicle tethering to Golgi. Each is linked with MAP4K5 in more than 16 cancer types. Because this analysis shows association rather than direction, both MAP4K5-to-partner and partner-to-MAP4K5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of cilium assembly grouped by MAP4K5-low versus MAP4K5-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP4K5→partner) and Y-score (partner→MAP4K5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Negative regulation of cilium assembly →	+0.092	+0.994	<.001	<.001	3	17
STOMACH	Microtubule polymerization →	+0.128	+1.183	<.001	<.001	3	16
OESOPHAGUS	Vesicle tethering to Golgi →	+0.122	+0.920	<.001	.001	3	15
BONE	Positive regulation of focal adhesion assembly →	+0.171	+0.628	<.001	<.001	3	15
STOMACH	Regulation of hippo signaling →	+0.110	+1.030	<.001	<.001	3	15
LUNG_NSCLC_LUSC	Negative regulation of organelle assembly →	+0.095	+0.858	.004	.002	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,327 associations by consensus.

Negative regulation of cilium assembly by MAP4K5 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →