MAP4K3-DT

Across TCGA pan-cancer cohorts, MAP4K3-DT RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated MAP4K3-DT data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher MAP4K3-DT RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MAP4K3-DT expression acts as an unfavorable survival marker, although some lineages such as KIRC and MESO show a favorable association.

UVM, UCEC, and KIRC are the cancer types where MAP4K3-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.389	0.787	<.001	132	view →
UCEC	DFS	Quartile	All	0.436	0.778	.003	44	view →
KIRC	DFS	Median	II,III,IV	0.862	0.646	.004	32	view →
HNSC	DFS	Tertile	All	0.238	0.413	.007	31	view →
CESC	DFS	Median	All	0.654	0.837	<.001	26	view →
KIRP	OS	Median	II,III,IV	0.494	0.926	.005	25	view →
ESCA	OS	Median	IV	0.222	0.698	.006	18	view →
MESO	OS	Tertile	All	0.484	0.300	.005	14	view →
CHOL	OS	Median	III,IV	0.286	1.000	.008	12	view →
LAML	DFS	Median	All	0.453	0.691	.012	12	view →
PRAD	DFS	Median	All	0.919	0.851	.020	10	view →
BLCA	OS	Median	IV	0.137	0.383	.005	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

MAP4K3-DT–UVM (OS)

Open the UVM breakdown →