MAP4K2

Across TCGA cell cohorts, MAP4K2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,261 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MAP4K2-associated GO terms across cancer lineages are Microtubule nucleation, Regulation of metaphase plate congression, and Tissue homeostasis. Each is linked with MAP4K2 in more than 10 cancer types. Because this analysis shows association rather than direction, both MAP4K2-to-partner and partner-to-MAP4K2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Microtubule nucleation grouped by MAP4K2-low versus MAP4K2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MAP4K2→partner) and Y-score (partner→MAP4K2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Microtubule nucleation →	+0.104	+1.079	.007	.003	3	11
BONE	Regulation of metaphase plate congression →	+0.163	+1.043	.005	.009	3	11
LARGE_INTESTINE	Tissue homeostasis →	-0.063	-0.914	<.001	<.001	3	10
BONE	Protein localization to microtubule organizing center →	+0.058	+0.884	.006	.003	3	10
BONE	Chromosome separation →	+0.162	+1.430	.002	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Spindle organization →	+0.071	+0.623	.001	<.001	2	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,261 associations by consensus.

Microtubule nucleation by MAP4K2 expression — BONE

Explore this box plot interactively →